We received a request through the website to perform an urgent investigation of a plant culture media to verify concentration of two carbohydrates and an antibiotic at a very low concentration. In addition, antibiotic did not have any UV absorbance, thus complicating its detection. Nevertheless, only two days later, a suitable LC-MS method was developed and successfully used to troubleshoot media preparation. Our client was able to uncover complex interactions between different media components and come up with a solution for a viable formulation.
One of our clients requested to develop a method for a very low abundance plant intermediate. Major obstacles were instability of this metabolite during sample preparation and its surfactant nature, which presented a significant challenge in its chromatographic separation. One of our clients was developing an inhalation formulation containing two actives at extremely low concentration.
One active was a lypopeptide with no chromophore, the other active was a phosphorothioate oligonucleotide with very unusual properties. The client turned to us after two other CROs failed to develop a viable assay, and thus critical animal studies were significantly delayed. We were able to develop suitable assays in a short timeframe and transfer the methods to the animal facility.
Drug development program has since progressed to the clinical stage. We had to turn to Alera Labs when our former CRO ran into major difficulties with drug product stability assessment. Alera Labs was able to develop and validate a challenging analytical method within an extremely short timeframe. This helped us start our clinical program on time.
LTI was introduced to Alera Labs when a client sourced them for their project. We look forward to working with them again in the future endeavors. Alera Labs has a great deal of experience with chemical analysis of the compounds in our market space. They have been very helpful in setting up and running HPLC assays suited to our specific needs with minimal investment.
They also provide super fast turnaround times on our analyses and this has significantly reduced our development times since we started working with them a few years ago. Alera Labs offers comprehensive impurities testing for both small and large molecule drug products or APIs. We can perform forced degradation studies, which will provide an insight into potential degradation pathways and their potential impact on pharmaceutical development.
Degrading related impurities can be characterized or identified by performing degradation studies under acidic, basic, oxidative, and various heat and light conditions. If you have a drug product or API that exhibits peaks in chromatograms that you would like to identify, we will assist with structure elucidation using LC-MS technique. Such studies are usually required during pre-clinical and early clinical stages. Major degradation products also need to be identified during forced degradation studies.
We will also gladly perform fast and efficient sample analysis either using a method provided by the client or developed by us. We will then analyze your bioanalytical samples within business days. Compare our average turnaround time to that of any larger CRO months and you will clearly see the difference.
We partner with several local labs that provide toxicologic services. Our scientists have expertise with virtually all possible classes of compounds and can find solutions to most difficult separations. Whether you are looking to quantitate a low level active compound with no UV chromophore or a highly labile compound, we can help solve your problem.
Ask us about validated, reliable biomarkers that can be used in your project. We can provide free analysis of markers appropriate for your pathway or set up quantitative assays for your marker of interest. Skip to content. Brochures Clients Speak Gallery Online payment. Read more. Method Development, Validation and Transfer. But he is far from safe, as trying to keep up the illusion of being a student while secretly training as one of the First Lord's spies is a dangerous game.
Ill-equipped to face this attack, Gaius must seek support - even from the combative High Lord of Aquitaine. Kalare has also seized valuable hostages that could mean the difference between victory and failure. And Amara, the First Lord's Cursor, has been tasked with their rescue. She has earned this trust but are her allies as worthy - or does the Lady Aquitaine see the time as ripe for betrayal?
The power-hungry High Lord of Kalare has launched a rebellion against the aging First Lord, Gaius Sextus, who with the loyal forces of Alera must fight beside the unlikeliest of allies - the equally contentious High Lord of Aquitaine.
Meanwhile, young Tavi of Calderon joins a newly formed legion under an assumed name even as the ruthless Kalare unites with the Canim, bestial enemies of the realm whose vast numbers spell certain doom for Alera.
In his acclaimed Codex Alera novels, best-selling author Jim Butcher has created a fascinating world in which the powerful forces of nature take physical form. For millennia, the people of Alera have used their unique bond with these elementals for protection. Now, as enemies become allies, and friends become bitter foes, a danger beyond reckoning looms.
Tavi of Calderon, now captain of his own Legion, has been fighting a bitter war for two years. Then he discovers the invading Canim warriors are harbingers of a far greater threat. The Canim are being hunted in their turn by a savage race that forced them from their homeland - and which has pursued them to the Aleran borders. With options fast running out, Tavi proposes an alliance with the Canim. After bitter fighting, Tavi of Calderon has eventually forged an alliance with Alera's oldest foes, the savage Canim, and he must escort them on their long sea-voyage home.
This will strain their fragile accord - but the worst is yet to come. The inhuman Vord have spent the last three years laying waste to the Canim homeland, making it a desolate place indeed. Then the Alerans become stranded there, cut off from their ships. Tavi of Calderon, now recognized as Princeps Gaius Octavian and heir to the crown, has achieved a fragile alliance with Alera's oldest foes, the savage Canim.
But when Tavi and his legions guide the Canim safely to their lands, his worst fears are realized. The dreaded Vord - the enemy of Aleran and Cane alike - have spent the last three years laying waste to the Canim homeland. And when the Alerans are cut off from their ships, they find themselves with no choice but to fight shoulder to shoulder if they are to survive.
The aging First Lord of Alera has fallen in battle. Yet his people must continue to resist an invading inhuman army. Desperate Alerans even pledge fealty to the Vord Queen to survive, turning the incredible power of Aleran furies back on their own people. And despite all efforts, the Alerans are being ground into dust and pushed to the farthest reaches of their own realm.
For years he has endured the endless trials and triumphs of a man whose skill and power could not be restrained. Battling ancient enemies, forging new alliances, and confronting the corruption within his own land, Gaius Octavian became a legendary man of war - and the rightful First Lord of Alera. But now, the savage Vord are on the march, and Gaius must lead his legions to the Calderon Valley to stand against them - using all of his intelligence, ingenuity, and furycraft to save their world from eternal darkness.
Codex Alera 12 books in series.
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Our Areas of Expertise · Employee Benefits · Property & Casualty · Wealth Services · Retirement Plan Services. Alera Details. Home · Products · Bookcases & Shelving · Carts & Stands · Chair Mats & Floor Mats · Chairs, Stools & Seating Accessories. Alera Group, formed in early , has over 3, employees serving thousands of clients nationally. We have specialists in employee benefits, property and.